apparati

When would you need high-fidelity template DNA at milligram-scale quantities within weeks? During a pandemic. We are screening for the most effective DNA polymerases for our proprietary continuous PCR technology to meet rapid response requirements for RNA vaccine medical countermeasures. We aim to meet pharmaceutical standards of quality suitable for RNA vaccines to improve safety and efficacy. With a robust PCR platform, Apparati further aims to expand continuous manufacturing for rapid response demands in gRNA gene-editing therapeutics and cancer therapeutics.

Enzyme catalysis is at the heart of our business and our technology. We need to make our products highly stable, functional, and at extremely large scales to meet unprecedented demands. Advancing the biomanufacturing of enzymes is a core function of our R&D activities. We are currently investigating different protein adhesion molecules that will reversibly immobilize enzymes onto solid support matrices without compromising activity.

Part of Apparati’s technological aim is to develop materials for solid-phase enzyme synthesis. The constraint with this technology is the cost of enzymes which have a relatively short half-life during catalysis. Apparati’s current strategy to offset the costs of utilizing high-value enzymes is to immobilize enzymes onto the surface of beads and continuously resurface the beads using an automated process with magnetic propulsion.

Sustainably derived nucleotides at an affordable price. By applying our platform technology to nucleotide processing, making RNAs and DNAs can be more affordable.

Lipid synthesis was a major bottle-neck in pandemic readiness for LNP vaccine production. With our platform technology,  lipids can be more sustainable, economical, and at a level of quality to meet the standards required for therapeutics, food ingredients, cosmetics, and consumer goods.

CFPS can overcome many obstacles from fermentation if it is economically efficient. Apparati’s platform may be able to scale up recombinant protein production by developing cost-effective components to sustain a CFPS system.